Plackett-Burman design,steepest ascent and response surface design were used to optimize the components and conditions of fermentation. The concentration of astaxanthin produced by UV-N2-7 was found to be 6.338 mg/L under the optimized conditions.

• 采用Plackett-Burman设计法及响应面分析法对发酵培养基的组分及发酵条件进行了优化；突变株的虾青素产量由从初始的2.；674 mg/L提高到了6