Progressive familial intrahepatic cholestasis (PFIC) is caused by mutations of the bile salt export pump or the multidrug resistance P-glycoprotein, resulting in chronic hepatic failure.

• 进行性家族性肝内胆汁淤积症(PFIC)是因为胆盐输出泵或多药耐药性P-糖蛋白突变的结果，常常导致慢性肝功能衰竭。