RNA in situ hybridization demonstrated positive ADAM12 mRNA in 12 cases of the detected tumors. The ADAM 12 mRNA positive signal was localized in the cytoplasm of almost all multinucleated giant cells and mononuclear stromal cells.

• RNA原位杂交则显示 12例骨巨细胞瘤组织全部呈ADAM12阳性反应 ,并且位于几乎所有的多核巨细胞和单核基质细胞胞质中。