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- Objective: To investigate the ghrombolytic effect of recombinant staphylokinase on caroid artery thrombus in rabbits. 目的:探讨重组葡激酶对颈动脉血栓的溶栓作用。
- AIM To investigate thrombolytic effect of recombinant staphylokinase in vitro and in vivo. 目的研究重组葡激酶对体内外血栓的溶解作用。
- Recombinant staphylokinase(r-SAK) was administered at a dose of 0.2 mg/kg through intravenous injection in 30 min. 双侧股动脉血栓随机分为重组葡激酶组（单用药组）和重组葡激酶加超声组（超声助溶组）。
- Methods The aim protein of recombinant staphylokinase induced using the activation and cultivation of bacteria and its content measured with SDS-PAGE. 方法：采用细菌活化和培养方法诱导目的蛋白，并用SDS-PAGE测其含量，应用层析技术纯化蛋白。
- Conclusion The engineering bacteria of induced aim protein of recombinant staphylokinase were successfully constructed.The high expression and purified protein was acquired. 结论：成功构建高效表达重组葡激酶的工程菌，并获得了高含量、高纯度的目的蛋白。
- Liu J X,Shang X H,Fu J H,et al.Effects of recombinant staphylokinase on coronary thrombesis in Chinese exporimental miniature swine[J].Acta Pharmacol Sin,2002,23(6):509. 于震;刘建勋;李欣志;等.;双参宁心胶囊对小型猪介入性心肌缺血的保护作用[J]
- Liu J X, Shang X H, Fu J H, et al.Effects of recombinant staphylokinase on coronary thrombosis in Chinese experimental miniature swine[J].Acta Pharmacol Sin, 2002,23(6):509. 于震;刘建勋，李欣志，等.;双参宁心胶囊对小型猪介入性心肌缺血的保护作用[J]
- To inspect the results of recombinant staphylokinase in the treatment of experimental central retinal artery occlusion,and also to observe the changes of fibrinolytic activity in the systemic circulation. 目的 :观察重组葡激酶 (recombinantstaphylokinase ,r-Sak)治疗实验性视网膜中央动脉阻塞的效果及其对全身的影响。
- recombinant staphylokinase ( r - Sak) 重组葡激酶
- Tolerability of recombinant staphylokinase in healthy subjects 重组葡激酶在健康受试者的耐受性
- Keywords recombinant staphylokinase;safety;tolerability; 重组葡激酶;安全性;耐受性;
- Pharmacokinetics of Recombinant Staphylokinase in Rats after Bolus Injection 重组葡激酶在大鼠静脉注射给药后的药代动力学
- Keywords Recombinant staphylokinase;Thrombus;Thrombolytic effect;Rabbit; 重组葡激酶;血栓;溶栓作用;兔;
- Keywords Recombinant staphylokinase;Bacterial fermentation;purification; 重组葡激酶;细菌发酵;纯化;
- Keywords recombinant staphylokinase;animal model;thrombolytic therapy; 重组葡激酶;动物模型;溶栓治疗;
- Keywords Ischemic stroke Recombinant staphylokinase Thrombolysis Urokinase; 缺血性卒中;溶栓;葡激酶;尿激酶;
- Recombinant staphylokinase: comparison of administration route in a pig model of thromboembolic stroke 重组葡激酶不同给药途径治疗幼猪急性脑栓塞的比较研究
- Biological assay and pharmacokinetics of recombinant staphylokinase in human plasma 人血浆中重组葡激酶的生物法含量测定及药动学
- Pharmacokinetics of recombinant staphylokinase in Chinese healthy volunteers after a single dose administration 单次静滴重组葡激酶在健康人体的药代动力学
- Intra-arterial thrombolysis with recombinant staphylokinase in a rabbit middle cerebral artery embolic stroke model 兔大脑中动脉栓塞模型的建立及初步应用
