Results: DES inhibitied the high bone turnover of deovarian rats,but ZGP mainly inhibitied bone resorption restrained and had no obvious inhibition to bone formation.

• 与己烯雌酚比较两者作用机制不同,增骨丸主要是抑制去卵巢大鼠的骨吸收,对骨形成无明显抑制作用,而己烯雌酚则主要是明显抑制大鼠去卵巢后引起的骨高转换。