Results: The osteoarthritis models were set up successfully.Intra-articular injection of SHI and fumigation with Chinese crude drug delayed arthrodial cartilage damage.

• 结果：成功建立动物模型，透明质酸钠关节内注射配合千草方薰洗治疗膝关节骨关节炎，能显著延缓关节软骨的破坏。