SR with HPMC helped to improve the properties of materials for direct compression and a simple method for preparing pentoxifylline sustained release tablets was provided.

• 结论 本研究中影响己酮可可碱缓释骨架片释放度的因素较少，联合使用HPMC可有利于改善直接压片物料的性能，为制备己酮可可碱缓释片提供了一种简便方法。