So far chemical synthesis has gradually replaced seaweed abstraction as a way to manufacture bulk drug mannitol.Chemical synthesis can cause the existence of a small amount of sorbitol in mannitol.

• 目前原料药甘露醇的生产已由化学合成法逐步代替海带提取法,化学合成法的原料药甘露醇中或多或少含有微量的山梨醇。