Some drugs accumulate, producing higher concentrations in cells than in ECF, most commonly because they bind with protein, phospholipids, or nucleic acids.

• 药物储库 药物在组织或机体腔室的积聚能延长药物在血浆中的逗留时间，从而延长药物作用时间，这是因为，当血浆药物浓度下降时，组织就会把贮存药物释放出来。