Some reports indicated the presence of estrogen receptor in bone tissue suggested that estrogen may directly act on bone cells by a mechanism mediated by receptor and improve the skeletal mineralization and remodeling .

• 据文献报道骨组织存在着雌激素受体，提示雌激素可以通过受体介导机制直接作用于骨组织细胞，改善骨组织的矿化和重建过程。