Tetramethylpyrazine phosphate concentration in infiltration media was determined by HPLC and influential factors on drug permeability through capsule bodies were studied.

• 方法灌注法制备非渗透性胶囊体,通过HPLC法测定渗透介质中药物磷酸川芎嗪的浓度,考察影响药物通过胶囊体渗出量的影响因素。