The DNA adduct formation and cytochrome P450 1A1 (CYP1A1) induction have been suggested to be the major determinant of their carcinogenic activity.

• 已知多环芳香烃对细胞色素P450 1A1 (CYP1A1) 之诱发能力和形成DNA键结物以及引起肿瘤形成呈正相关性。