The Rb gene abnormality was one of the hereditary factors associated with the occurrence of lung cancer, and the abnormal Rb gene was found in 90% of small cell lung cancer (SCLC) and 10 -30% of non - small cell lung cancer ( NSCLC).

• 在小细胞肺癌(SCLC)约90%25，非小细胞肺癌(NSCLC)约10-30%25存在Rb基因异常，Rb基因异常者因肺癌死亡的危险性比正常人高15倍，是肺癌发生的遗传因素之一。