The advances made in the new compounds identified as Protein Tyrosine Phosphatases 1B (PTP1B) inhibitors recently and their structure-activity relationship were reviewed in this paper.

• 介绍了最近几年来关于酪氨酸蛋白磷酸酯酶1B作用的机制以及通过各种途径发现的结构新颖的小分子抑制剂的构效关系研究进展。