The alkaloids, water layer constituents and total flavonoide aglycone showed strong antibacterial activity against Staphalococus aureus and Escherichia coli.

• 大叶冬青叶水层物总生物碱、总黄酮甙元对金黄色葡萄球菌和大肠杆菌均有较强的抑菌活性。