The changes of Treg and CD4~+CD28~-T cells may lead to breakdown of peripheral autoimmune tolerance and play an important role in the developmant and progression of CHD.

• 结论不稳定性心绞痛患者外周血Treg比例减少而CD4+CD28-T细胞比例升高,Treg比例降低可能使外周免疫耐受失去平衡,参与了动脉粥样硬化的发生发展。