The content of superoxide dismutase(SOD),MDA and hydroxyproline in the skin tissue homogenate of the mice s back and the fibroblast amount in the skin were examined 42 days after the treatment.

• 结果:二至丸低、中、高剂量均能明显升高亚急性衰老小鼠皮肤SOD活力,使其MDA含量明显下降,增加衰老小鼠皮肤羟脯氨酸含量,提高皮肤成纤维细胞数目。