The data indicated ET system may play a key role in CPH.However, it remains much contravention about expression of ETRs and effect of ETR antagonists on portal hypertension (PHT) up to now.

• 但是，目前对于内皮素系统在肝硬化门脉高压症形成中的作用和地位还存在着诸多争论，ETR拮抗剂对门脉高压的血流动力学影响的研究结果也不一致。