The degeneration and disappear of dopaminergic neurons in the substantia nigra pars compacta induces the functional disorder of the efferent nuclei in basal ganglia circuity.

• 该病是由基底节黑质致密部多巴胺（dopamine，DA）能神经元的变性缺失导致该运动调控环路传出核团功能亢进而引起的。