The early clinical features of MCTD are nonspecific, and may consist of general malaise, arthralgias, myalgias, and low-grade fever.

• 混合性结缔组织疾病早期的表现并不具特异性，常只是全身倦怠，关节肌肉酸痛及低热，较特异的发现是抗核抗体的生成。