The examination of heart,liver and kidney function was determined by creatine kinase(CK) and the isoenzyme CK-MB, lactate dehydrogenase(LDH) and the isoenzyme LDH1, AST, ALT, creatinine(CREA).

• 对不同DOX累积剂量的实验犬进行剖检，取心肌、肝、脾、肺、肾组织在光镜下观察病理变化，取心脏左心室心肌组织观察电镜下心肌超微结构变化。