The exon20 (locus 18109T/C) poly- morphism of HMGCR gene is correlated with HBV in- fection, and patients with C/C genotype are more suc- ceptible to become AsCs after HBV infection.

• Hardy-Weinberg平衡拟合度检验优良；说明所收集人群具有良好的代表性; 其次首次证实HMGCR基因20外显子18109T/C多态性与慢性乙型肝炎有关联存在.