The expression of MDR1 mRNA and Pgp in HL60/DNR are strong positive. The intracellular concentration after uptake and retention of R123 in HL60 is 50 times more than that in HL60/DNR.
英
美
- HL60/DNR在mRNA水平高度表达MDRI,在蛋白质水平高度表达Pgp,功能性试验中细胞内R123最终浓度HL60为HL60/DNR的50倍。