The expression of MDR1 mRNA and Pgp in HL60/DNR are strong positive. The intracellular concentration after uptake and retention of R123 in HL60 is 50 times more than that in HL60/DNR.

• HL60/DNR在mRNA水平高度表达MDRI，在蛋白质水平高度表达Pgp，功能性试验中细胞内R123最终浓度HL60为HL60/DNR的50倍。