The first signal is evoked by the T-cell receptor after engagement with the major histocompatibililty complex-peptide complex expressed on the surface of antigen-presenting cells (APCs).
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- 当T细胞受体(T cell receptor TCR)与存在于抗原呈递细胞(antigen presenting cell APC)表面的主要组织相容性复合物(major histocompatibility complex MHC)相结合后,第一信号被激活;