The fluorescence intensity in SGC7901/Adr cells was much lower,indi- cating that the decrease of drug accumulation in SGC7901/Adr cells might contribute to the devel- opment of the multidrug resistance of SGC7901/Adr.

• 应用流式细胞术检测细胞阿霉素荧光强度,发现 SCG7901/Adr 细胞内阿霉素浓度明显低于 SGC7901,提示细胞内药物蓄积减少是导致SGC7901/Adr 产生多药耐药性的主要原因。