The gene products of p53, C-erbB-2, p21WAF1, CDK4 play a key role in the oncogenesis and development of breast cancer. Their expression could be useful indexes to assess the malignant level and clinical prognosis of breast carcinoma.

• p53、C-erbB-2、p21WAF1和CDK4与乳腺癌的发生发展密切相关,可作为判断肿瘤浸润转移、指导治疗和估计预后的参考指标。