The important influence factors to TCMF are due to the difference of the main contents of TCM, the Cosin method is better for similarity evaluation than Correlation method.

• 中药指纹图谱相似度的影响因素由样品所含的主要化学成分所引起,相关系数法比夹角余弦法对指纹图谱中小色谱峰变化的反应明显。