The level of S. sobrinus in saliva and Keyes scores representing the incidence of caries were recorded at the end of the experiment.

• 实验结束时采集大鼠刺激性唾液,制备牙颌骨标本,记录唾液远缘链球菌水平和 Keyes龋齿记分。 实验过程中同时记录安全性评价指标。