The main ADRs observed were acratia, myalgias, bone pain and fever and they were tolerable.No significant differences in ADRs were observed among groups.

• 结果：9例患者均按计划安全完成临床试验，主要不良反应为乏力、肌肉酸痛、骨痛、发热，但均可耐受，不同剂量组之间不良反应发生率和发生程度差异不显著。