The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion.

• 基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。