The multitarget therapy of selectively inducing thrombosis in tumor blood vessels can be achieved by the combination of tTF/SA, as a universal effector, and biotinlated carriers directing to tumor blood vessels.

• 融合蛋白tTF/SA可作为通用效应因子,与生物素化的肿瘤组织血管特异性载体联用,实现选择性诱发肿瘤组织血管栓塞的多点治疗。