The oversea current circumstances of the use of QSAR in estrogenic activity evaluation are described in this article with a particular emphasis on the building methods of xoestrogen QSAR Model.

• 类雌激素QSAR模型从化合物的分子结构、性质与其生物活性之间的关联出发,寻找类雌激素物质产生内分泌干扰的贡献结构,已经成为类雌激素物质活性评价和初步筛选的有效工具。