The overseas study showed kindled-rats respond differently to phenitoin (PHT), penobarbital (PB) and other classical AEDs and the drug-resistant kindled-rats could be screened out with the index of after-discharge threshold.

• 国外有研究发现大鼠点燃模型对苯妥英纳(PHT),苯巴比妥(PB)等经典的抗癫痫药物(antiepticdrugs,AEDs)有不同反应,以后放电阈值(After discharge threshold,ADT)为评价指标可筛选出耐药的点燃鼠。