The primary end point was disease exacerbation, defined as a Mayo Clinic clinical symptom score of 5 or more and an increase of 1 point or more in the Mayo Clinic flexible sigmoidoscopy score.

• 试验的终点以病况的恶化程度为依据，并定义为梅约医学中心临床症状分数5以上，及梅约软式乙状结肠镜检评分增加1分。