The results of this investigation showed that the expression of numerous genes involving in the BCR signaling pathways was down,regulated during the LPS,induced B cell differentiation.

• LPS诱导的原代B淋巴细胞的分化伴随着B淋巴细胞抗原受体(BCR)信号转导相关分子表达的显著降低,说明BCR的功能在浆细胞阶段已处于次要的地位。