The results suggest that in the process of formation of SU,ET 1 may be synthesized and secreted by gastric mucosa of CRS rats,and plays an important role in the pathogenesis of SU.

• 提示在冷束缚应激诱导大鼠SU形成过程中 ,胃粘膜组织局部可大量增加ET 1的合成、分泌 ,从而参与SU的病理生理过程 ,可能是胃粘膜损伤的重要致病因子。