The synthesis and release of CNP are regulated by many cy-tokines, and CNP is metabolized by two main pathways : internalization and degradation through the binding with NPR-C or hydrolysis by neutral endopeptidase.

• CNP的合成和释放受多种细胞因子的调节,通过与NPR-C结合而内吞或直接被中性内肽酶水解两条途径降解。