There are lowered plasminogen activities in early DN, t-PA and PAI could be evidences of kidney damage degree of DM, which could play significant roles in guiding administer to delay development of DN.

• DN早期即有纤溶活性低下; t-PA和PAI可能作为DN肾脏损害程度的佐证,对指导临床用药以缓解或延迟DN的发生具有重要意义。