There are some neutralization locations in the VP3 of hepatitis A virus and VP2 and VP3 of poliovirus indicates that the YP3 of AEV maybe in some degree function as protection protein resisting infection of virus.

• 小RNA病毒科中,结构蛋白VP3被认为与病毒的持续感染、T细胞免疫以及与病毒受体的相互作用有关,近期研究还表明AEV的结构蛋白VP3能够诱导宿主细胞的凋亡。