This is the first eidence of direct mutation of AKT1 in human cancer tumors: it was discoered in clinical samples from cancer patients, yet has neer been detected in cancer cell lines.

• 这是首次在人类肿瘤细胞中发现AKT1突变的直接证据，结果都是从临床样本中检测到的，而在肿瘤细胞株中尚未报道过此突变。