Through PACE, PCR, PCR-SSCP, RT-PCR, DNA sequences analysis, mRNA differently expression technique etc, we studied the molecular mechanism of the effect from the relation between genes mutation and the effect to genes expression and regulation.

• 同时采用PAGE、PCR、PCR-SSCP、RT-PCR、DNA序列分析、mRNA基因表达,DD RT-PCR等技术,进行了系统地基因分析,从基因突变与疗效关系,基因表达与调控等方面研究临床疗效的分子机理。