Through b ind ing to its receptor,TPO can induce receptor d im eriza-tion and tyrosine phosphorylation,and then activate a series of signaling pathways,inc lud ing JAK /STAT,Shc /Ras/MAPK and PI3K /Akt.

• TPO与其受体c-Mp l结合后,c-Mp l形成同源二聚体,激活JAK/STAT、Shc/Ras/MAPK、PI3K/Akt等信号通路,引发一系列生理效应。