To clear the mechanism of the chemotaxis, the effects of PI3 K, p38 and ERK on actin polymerization were studied with the inhibitors of these kinases in neutrophil like, differentiated HL 60 cells stimulated with fMLP.

• 为了澄清这种趋化反应的发生机理 ；将HL 6 0细胞诱导分化为中性粒细胞样细胞 ；然后利用激酶特异性抑制剂研究了在fMLP刺激下细胞内PI3 K、p38和ERK激酶在肌动蛋白聚合中的作用 .