To determine the interaction between polymorphisms of MMP-3, VDR-Taq, VDR-Apa and the susceptibility to lumber disc degeneration, the combined effects were analyzed.

• 对三个基因多态位点进行叉生分析，发现MMP-3基因携带5A等位基因的个体，同时VDR-Apa基因携带A等位基因，腰椎间盘退变的危险性增至3.；44，表明这两种等位基因同时存在对腰椎间盘退变有交互作用。