To observe the anti caries effects of a small dose of the surface protein antigen P1. The SD rats were immunized with P1 CTB and P1 PCG through IN (intrnasal immunization) and IG (intragastric immunization).

• 作者通过不同的粘膜途径免疫大鼠 ,观察变形链球菌表面蛋白 P1的免疫防龋效果。 将偶联抗原 P1- CTB,P1- PCG经胃肠道 (IG)和鼻腔 (IN)免疫后 ,观察大鼠的患龋情况。