Topical agents are often unable to fully control severe atopic dermatitis, but while systemic therapies can be effective, continuous use of such agents is limited by end-organ toxicities.

• 局部药物通常不能完全控制重度特应性皮炎的病情，而系统性治疗是有效的，但是终末器官的毒性限制了这些药物的持续应用。