Treatment-induced damage to bone may occur rapidly or insidiously and can occur during primary treatment of the cancer or during maintenance adjuvant therapy.

• 治疗所导致的骨骼损伤可以发生得非常迅速或者又很隐匿，并且可以在治疗的初期就表现出来或者在长期维持性治疗后才开始显现。