Trimethylacctic acid, obtained by reaction of isobutanol with formic acid in the presence of sulfurric acid in 85% was treated with phosphorus trichloride, toyield trimethylacetyl chloride in 87%.

• 本文采用异丁醇与甲醇在硫酸介质中反应，制备了三甲基乙酸，收率为85%25。