Tumor growth can be promoted by PDGF via autocrine stimulation of malignant cells, overexpression or overactivation of PDGFRs, or stimulation of angiogenesis within the tumor.

• PDGF在肿瘤中的自分泌刺激、PDGFR的过表达或过度活化或者刺激肿瘤内血管生成都会促进肿瘤生长；