Upon enrollment, participants were aged42 to52; all had an intact uterus and at least one ovary and had had one or more menstrual periods during the previous3 months.

• 在登记人群中，参与者的年龄从42岁到52岁；所有人均有完整的子宫，至少有一枚卵巢，并且在前三个月中有一次或者一次以上的月经期。